نبذه عن الكتاب: With the near-completion of the human genome project, we are entering the exciting era in which one can begin to elucidate the relationship between DNA sequence variation and susceptibility to disease, as modified by environmental factors. Single nucleotide polymorphisms (SNPs) are by far the most prevalent of all DNA sequence variations. Although the vast majority of the SNPs are found in noncoding regions of the genome, and most of the SNPs found in coding regions do not change the gene products in deleterious ways, SNPs are thought to be the basis for much of the genetic variation found in humans. As explained eloquently by Lisa Brooks in Chapter 1 of Single Nucleotide Polymorphisms: Methods and Protocols, SNPs are the markers of choice in complex disease mapping and will be the focus of the next phase of the human genome project. Besides the obvious applications in human disease studies, SNPs are also extremely useful in genetic studies of all organisms, from model organisms to commercially important plants and animals