نبذه عن الكتاب: CONTENTS Preface vii 1 Evolution as Engineering Richard C. Lewontin 1 I Computational Biology 11 2 Analysis of Bacteriophage T4 Based on the Completed DNA Sequence Elizabeth Kutter 13 3 The Identification of Protein Functional Patterns Temple F. Smith, Richard Lathrop, and Fred E. Cohen 29 4 Comparative Genomics: A New Integrative Biology Robert J. Robbins 63 5 On Genomes and Cosmologies Antoine Danchin 91 II Regulation, Metabolism, and Differentiation: Experimental and Theoretical Integration 113 6 A Kinetic Formalism for Integrative Molecular Biology: Manifestation in Biochemical Systems Theory and Use in Elucidating Design Principles for Gene Circuits Michael A. Savageau 115 7 Genome Analysis and Global Regulation in Escherichia coli Frederick C. Neidhardt 147 8 Feedback Loops: The Wheels of Regulatory Networks Ren¨¦ Thomas 167 ¡¡ 9 Integrative Representations of the Regulation of Gene Expression Julio Collado-Vides 179 10 Eukaryotic Transcription Thomas Oehler and Leonard Guarente 205 11 Analysis of Complex Metabolic Pathways Michael L. Mavrovouniotis 211 12 Where Do Biochemical Pathways Lead? Jack Cohen and Sean H. Rice 239 13 Gene Circuits and Their Uses John Reinitz and David H. Sharp 253 14 Fallback Positions and Fossils in Gene Regulation Boris Magasanik 273 15 The Language of the Genes Robert C. Berwick 281 Glossary 297 References 303 Contributors 331 Index 335