📘 ❞ New stabilising groups for lateral lithiation of ortho-cresol derivatives ❝ كتاب

كتب علمية - 📖 كتاب ❞ New stabilising groups for lateral lithiation of ortho-cresol derivatives ❝ 📖

█ _ 0 حصريا كتاب ❞ New stabilising groups for lateral lithiation of ortho cresol derivatives ❝ 2025 derivatives: orthocresol من كتب علمية James A Wilkinson New derivatives and a new route to 2 substituted chromans James Wilkinson *, Eun Ang Raiber, Sylvie Ducki Centre Molecular Drug Design, Biosciences Research Institute, Cockcroft Building, University Salford, Salford M5 4WT, UK a r t i c l e n f o Article history: Received 30 January 2008 Received in revised form 4 April 2008 Accepted 24 2008 Available online 29 2008 Keywords: Lateral lithiation Alkylation ortho Cresol Chromans a b s t 2 (2 Methoxyethoxy) toluene and dimethylaminoethoxy) have been lithiated using sec BuLi under variety conditions the laterally species trapped with electrophiles, including but 1 ene oxide, leading synthesis ethylchroman 2008 Elsevier Ltd All rights reserved 1 Introduction Lateral is an important methodology organic Lateral benzenoid aromatics requires stabilising group capable either delocalising negative charge or stabilising organolithium by coordination Oxygen based stabilising groups placed position used for a number lithiations but are problematic case of simple The methoxy group requires superbase effect deprotonation methoxymethyl group gives exclusive (Scheme 1) 3 In previous work on diarylmethane we used the methoxyethoxy efficient This led us to investigate use same as potentially more efficient stabiliser We recently reported reactions orthocresol derivatives both dimethylaminoethoxy stabilising 5 Here, report full results of these investigations مجاناً PDF اونلاين الطريقة العلمية أو المنهج العلمي الثقافة عبارة عن مجموعة التقنيات والطرق المصممة لفحص الظواهر والمعارف المكتشفة المراقبة حديثا من ضمن محتويات القسم : العلماء‏ , أحيائية,‏ بيئية لا خيالية,‏ رياضيات,‏ طب‏, علم والكثير