█ _ 0 حصريا كتاب Florfenicol 2024 Florfenicol: من كتب طب بيطرى © 2007 The United States Pharmacopeial Convention All rights reserved 1 FLORFENICOL (Veterinary—Systemic) Some commonly used brand names for veterinary labeled products are: Aquaflor and Nuflor Note: For a listing of dosage forms and brand by country availability, see the Dosage Forms section(s) Category: Antibacterial (systemic) Indications text between EL US and EL describes uses that are not included in U S product labeling Text EL CAN and EL that in Canadian The EL US or EL CAN designation can signify lack availability indicated See Forms section this monograph to confirm availability General considerations Florfenicol is broad spectrum, pr imarily bacteriostatic, antibiotic with range activity similar to chloramphenicol, including many gram negative positive organisms; {R 1} however, florfenicol does carry risk inducing human aplastic anemia asso ciated with chloramphenicol {R 13} Florfenicol has been dem onstrated be active vitro vivo against Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, Haemophilus somnus 1; 2} In studies have demonstrated against Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Shigella dysenteriae {R 2; 15; 16} but at least 2 10 fold higher minimum inhibitory con centration than for Mannheimia, species listed above 16} It also some resistant strains bacteria, {R 17} possibly because it less affected by major enzyme produced in plasmid mediated bacterial resistance chloram phenicol thiamphenicol 26} Although obligate anaerobes not addressed literature, is likely quite effective 28} Accepted EL CAN Enteric septicemia (treatment) EL — Catfish: Type A medicated article the control mortality due enteric caused by susceptible Edwardsiella ictaluri 36} EL US Furunculosis (treatment) EL — Salmon: treatment furunculosis caused Aeromonas salmonicida 11} EL US Keratoconjunctivitis, infectious (treatment) EL — Cattle: injection treatment bovine keratoconjunctivitis Moraxella bovis 3; 33; 34} Pneumonia, (treatment)— Cattle: injection bacterial pneumonia associated respiratory infections (bovine disease complex) cattle susceptible H somnus, M haemolytica, and P multocida 3} EL CAN Florfenicol cattle high developing infection P EL {R 1; 32} Pigs : EL CAN Florfenicol oral solution EL EL US florfenicol injection EL are associated infec tions Actinobacillus pleuropneumoniae, P multocida, EL CAN Salmonella choleraesuis, Streptococcus suis Type 2 EL 37} Pododermatitis, (treatment)— Cattle: indicated of pododermatitis (interdigital phlegmon) Bacteroides melaninogenicus Fusobacterium necrophorum 30} Regulatory Considerations U — Withdrawal times estab lished catfish cattle; however, use lactating dairy or veal calves (see section) 36} Canada— esta blished salmon; labeled dairy cattle or calves (see 11} Chemistry Source: A fluorinated derivative 12} Chemical name: Acetamide, 2,2 dichloro N [1 (flouromethyl) hydroxy [4 (methylsulfonyl)phenyl]ethyl] [ R ( R*,S* )] 4} Molecular formula: C 12 H 14 C l2 FNO 4 S 14} Molecular weight: 358 21 4} Description: Melting point 153 154 ̊ C 12} Solubility: Soluble water 12; 13} Lipid soluble 13} Pharmacology Pharmacokinetics Mechanism action Effect: bacteriostatic antibiotic inhibits protein synthesis binding ribosomal subunits bacteria , leading inhibition peptidyl transferase {R 13; 26} and thereby preventing transfer amino acids growing peptide chains subsequent formation receptor site florfenicol considered same as chloramphenicol 26} In bovine disease, may bactericidal Mannheimia ( Pasteurella) hemolytica Pasteurella when administered achieve minimum concentrations (MICs); {R 14} (MBCs) very close MICs fluorine atom instead hydroxyl group located at C 3 structure ch loramphenicol 13} This allow be deactivation bacteria transm issible resistance involves acetylation group thiamphenicol, prevents th eir interaction ribosomes 26} Other actions effects: Florfenicol, like thiamphenicol, lacks nitro on aromatic ring been with induced, non–dose related, irreversible aplastic people 24; 25} However, thiamphenico l cause dose dependent, reversible bone marrow suppression animals people {R 13} due mitochondrial injury 24} theoretically possible coul d suppression, but clinically reported 13} Absorption: Bioavailability— Intramuscular administration: Calves, 3 6 months age—78 5% (range 59 106%), 20 mg per kg body weight (mg kg) 2; 8} Cattle, lactating—38 ± 14%, 9} Horses —81%, 22 kg مجاناً PDF اونلاين الطب البيطري (بالإنجليزية: Veterinary medicine) أو البيطرة هو تطبيق المبادئ الطبية والتشخيصية والعلاجية الحيوانات الإنتاجية والمنزلية والبرية يحتوي هذا القسم علي العديد الكتب المتميزة حول المجال يمارس عادة عيادة بيطرية مستشفى بيطري المزرعة للطب دور كبير حماية البشر الأمراض التي تنتقل عن طريق الأكل أصبح التخصص شائعاً السنوات الأخيرة ومن تلك التخصصات: التخدير علم السلوك الجلدية الحالات الطارئة والعناية الحثيثة الباطني امراض القلب السرطان العيون الأعصاب المشتركة المعدية التناسليات والولادة التصوير الشعاعي والجراحة