█ _ 0 حصريا كتاب Comparative pharmacokinetics of sulfamethazine after intravenous administration in bovine (Bos taurus) and buffalo (Bubalis bubalis) calves 2024 calves: من كتب طب بيطرى Comparative marbofloxacin a single intramuscular at two dosages to camels ( Camelus dromedarius ) R LARAJE* A TALMI* R BOUNAGA M BENGOUMI A EL HRAIKI & M LAURENTIE * Laboratoire National de Contro ˆ le des Me ́ dicaments Ve ́ te ́ rinaires, Rue Ikhlass, Cite ́ Yakoub El Mansour, Rabat; Institut Agronomique et Ve ́ rinaire Hassan II, Rabat, Morocco; AFSSA Fouge ` res, LERMVD, Unite ́ pharmacocine ́ tique Pharmacodynamie, Fouge ` res Cedex, France (Paper received 9 December 2005; accepted for publication 20 February 2006) M Laurentie, AFSSA BP 90203, 35302 Cedex, France E mail: m laurentie@fougeres afssa fr Marbofloxacin is fluoroquinolone antimicrobial agent used exclusively veterinary medicine This has broad spectrum microbial activity including most aerobic Gram negative some positive bacteria Its spectrum of pharmacokinetic profile suggest good tissue penetration making this drug suitable second choice treatment especially dermatological pulmonary infections Mar bofloxacin mainly eliminated urine its active form making it alternative the treatment urinary tract infections (Schneider et al , 1996) A previous study shown that main clinical problems adult dromedaries are dermatological whereas young dromedaries infectious diarrhoea major importance (Bengoumi & Faye, 2002) Marbofloxacin might be suitable antimicrobial these diseases the camel The are well documented species, but not purpose of present was investigate disposition this fluoroquinolone following single dose dosage 2 4 mg kg b w intramuscularly (i ) The carried out on five healthy male camels, 5– 13 years old ranging body weight from 291 535 They were individually stabled fed barley (2 day each) had free access hay water No drugs been administered previously animals All administered 10% aqueous solution of the base form (Ve ́ toquinol, Lure, France) a dose , i right thigh After wash out period weeks, same same solution dose Blood samples (10 mL) collected jugular vein just before 5, 10, 15, 30, 45 min, 1, 2, 3, 4, 6, 8, 12, 16, 24, 36, 48, 72 96 h Blood samples centrifuged (2600 g for 10 min) plasma was stored at ) 20 ° C until analysis plasma concentration determined by reverse phase high performance liquid chromatography with UV detection (295 nm) using method described by Schneider et (1996) standard curve in camel linear between 1 5 l g mL with a determination coefficient ( r 2 ) 99 8% recovery measured on interval 96% intra inter assay coefficients variation below 5% limit quantifica tion established 1 l g Both compartmental statistical moment approaches were used analyse concentration–time data mar nonlinear regression analysis program (Winonlin 01; Pharsight Inc Mountain View, CA, USA) One compartment open models tested using first order absorption without lag time The best fitting model selected Akaike’s Information Criterion (Yamaoka et 1978) Classical pharmacokinetic parameters calculated equations (Gibaldi & Perrier, 1982) observed maximum ( C maxobs ) and when concentrations occurred ( t max ) have also been indicated relative bioavailability ( F ) the equation: مجاناً PDF اونلاين الطب البيطري (بالإنجليزية: Veterinary medicine) أو البيطرة هو تطبيق المبادئ الطبية والتشخيصية والعلاجية الحيوانات الإنتاجية والمنزلية والبرية يحتوي هذا القسم علي العديد الكتب المتميزة حول المجال يمارس عادة عيادة بيطرية مستشفى بيطري المزرعة للطب دور كبير حماية البشر الأمراض التي تنتقل عن طريق الأكل أصبح التخصص شائعاً السنوات الأخيرة ومن تلك التخصصات: التخدير علم السلوك الجلدية الحالات الطارئة والعناية الحثيثة الباطني امراض القلب السرطان العيون الأعصاب المشتركة المعدية التناسليات والولادة التصوير الشعاعي والجراحة