█ _ 0 حصريا كتاب ❞ Comparative pharmacokinetics of ivermectin after its subcutaneous administration in healthy sheep and infected with mange ❝ 2024 mange: من كتب طب بيطرى Comparative subcutaneous administration mange J ECHEVERRI ́ A* , N MESTORINO* , & J O ERRECALDE* , *Ca ́ tedra de Farmacologı ́ a, Farmacotecnia y Terape ́ utica, Facultad Ciencias Veterinarias, Universidad Nacional La Plata, Plata, Argentina; INCAM, Vero ́ nica Experimental Station, Argentina; (Paper received: 21 March 2001; accepted for publication 19 November 2001) Correspondence (e mail: jerrecal@fcv unlp edu ar) It is well established that the efficacy any anthelmintic drug depends not only on affinity specific parasite target sites but also ability to reach high sustained drug concentrations where parasites are located Ivermectin one most useful anti parasitic agents It belongs family avermectins highly lipophilic macrocyclic lactones It a fermentation product of Streptomyces avermitilis One important characteristics iver mectin wide spectrum activity involving endo and ectoparasites effective when it applied orally, parenterally or topically Its absorption rapid by these routes of administration (Campbell, 1989, 1993) Mange an ectoparasitic disease produced mite Psoroptes ovis has major economic importance South America, especially Argentina, Chile Uruguay antici pated diseased animal there kinetic modifications largely dependent change body condition The objective of present paper was determine pharmacokinetic changes subcutaneously healthy animals animals carrying natural infections Six adult (weighing 50 ± 6 kg) five sheep naturally infested psoroptic mites showing mange lesions at least 30% their surface (weighing 43 received 200 l g kg subcutaneously, the sampling times being following post days: 0 5, 1, 2, 3, 4, 6, 8, 10, 12, 15, 18, 20, 25 30 Plasma was separated centrifugation kept frozen at ) 20 ° C until assayed Assay performed performance liquid chromatography (HPLC) recovery 85% the quantitation limit 1 ng mL Variability lower than 8% HPLC system Shimadzu LC 10 AS pump TM III 1311 model fluoromonitor column C8 reverse phase lichrospher mobile phase glacial acetic acid methanol acetonitrile (9:200:291 mL) flow rate 5 min Reagents were grade Extraction accomplished by solid–liquid method C18 cartridges eluate was evaporated, derivatizated injected into system (Alvinerie et al , 1987) Pharmacokinetic analysis wa مجاناً PDF اونلاين الطب البيطري (بالإنجليزية: Veterinary medicine) أو البيطرة هو تطبيق المبادئ الطبية والتشخيصية والعلاجية الحيوانات الإنتاجية والمنزلية والبرية يحتوي هذا القسم علي العديد الكتب المتميزة حول المجال يمارس عادة عيادة بيطرية مستشفى بيطري المزرعة للطب دور كبير حماية البشر الأمراض التي تنتقل عن طريق الأكل أصبح التخصص شائعاً السنوات الأخيرة ومن تلك التخصصات: التخدير علم السلوك الجلدية الحالات الطارئة والعناية الحثيثة الباطني امراض القلب السرطان العيون الأعصاب المشتركة المعدية التناسليات والولادة التصوير الشعاعي والجراحة