📘 ❞ (Gene Expression Profiling_ Methods and ❝ كتاب ــ Richard A. Shimkets اصدار 2004
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█ _ Richard A Shimkets 2004 حصريا كتاب ❞ (Gene Expression Profiling_ Methods and ❝ 2024 and: نبذه عن الكتاب: Technical Considerations in Quantitating Gene Expression Richard Shimkets 1 Introduction Scientists routinely lecture write about gene expression the abundance of transcripts, but in reality, they extrapolate this information from a variety measurements that different technologies may provide Indeed, there are many reasons applying to transcript may give results This result an incomplete understanding the gene question or shortcomings applications The first key factor appreciate measuring is way that genes are organized how influences transcripts cell Figure 1 depicts some scenarios have been determined sequence analyses of human genome Most genes composed multiple exons transcribed with intron sequences then spliced together Some exist entirely between other genes, either forward reverse orientation This poses problem because it possible recover fragment clone that could belong be derived unspliced transcript, be the genomic DNA contaminating RNA preparation All these events can create confusing confounding Additionally, duplication events occurred organisms more complex led to existence closely related families coincidentally lie near each In addition, although probably less than 50,000 human within those variety of ways, with documented produce 100 ( Biology Books مجاناً PDF اونلاين Biologically Biology natural science concerned study life, its various forms function, these interact each surrounding environment The word biology Greek made up two words: bio (βίος) meaning life And loggia ( λογία) means Biology: similarity vegetation animal cover on edges African American states, same fossil Branches biology Biology ancient thousands years old modern began nineteenth century has branches Among them are: Anatomy Botany Biochemia Biogeography Biofisia Cytology science Ecology environmental science Development Embryology embryology Genetics genetics Histology histology Anthropology anthropology Microbiology bacteriology Molecular Biology Physiology functions organs Taxonemia taxonomy Virology virology Zoology zoology
كتاب
(Gene Expression Profiling_ Methods and
ــ Richard A. Shimkets
صدر 2004م
كتاب
(Gene Expression Profiling_ Methods and
ــ Richard A. Shimkets
صدر 2004منبذه عن الكتاب:
Technical Considerations
in Quantitating Gene Expression
Richard A. Shimkets
1. Introduction
Scientists routinely lecture and write about gene expression and the abundance of transcripts, but in reality, they extrapolate this information from a variety of measurements that different technologies may provide. Indeed, there are
many reasons that applying different technologies to transcript abundance may
give different results. This may result from an incomplete understanding of the
gene in question or from shortcomings in the applications of the technologies.
The first key factor to appreciate in measuring gene expression is the way that
genes are organized and how this influences the transcripts in a cell. Figure 1
depicts some of the scenarios that have been determined from sequence analyses
of the human genome. Most genes are composed of multiple exons transcribed
with intron sequences and then spliced together. Some genes exist entirely
between the exons of other genes, either in the forward or reverse orientation.
This poses a problem because it is possible to recover a fragment or clone that
could belong to multiple genes, be derived from an unspliced transcript, or be
the result of genomic DNA contaminating the RNA preparation. All of these
events can create confusing and confounding results. Additionally, the gene duplication events that have occurred in organisms that are more complex have led
to the existence of closely related gene families that coincidentally may lie near
each other in the genome. In addition, although there are probably less than 50,000
human genes, the exons within those genes can be spliced together in a variety
of ways, with some genes documented to produce more than 100 different transcripts (
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