📘 ❞ Cancer Cell Signaling Methods and Protocols ❝ كتاب ــ David M. Terrian اصدار 2010
Biology Books - 📖 كتاب ❞ Cancer Cell Signaling Methods and Protocols ❝ ــ David M. Terrian 📖
█ _ David M Terrian 2010 حصريا كتاب ❞ Cancer Cell Signaling Methods and Protocols ❝ 2025 Protocols: نبذه عن الكتاب: 1 Introduction The discovery of tumor suppressor genes, whose loss predisposes to tumor development, has revolutionized the molecular analysis cancer (1–3) By definition, genes are genetically linked a For example, the retinoblastoma (RB) was first identified as gene that was specifically lost in familial RB (4–6) The majority suppressors 4 Knudsen Angus has been based on linkage subsequent epidemiological studies, however, initial understanding their mode action relatively limited As number suppressors increased, the mechanism through which function become an important aspect biology In general, tumors exhibit uncontrolled proliferation This phenotype can arise from that regulate progression cell cycle (e g , or p16ink4a) upstream mitogenic signaling NF1 PTEN) cascades (1,3,7–9) Thus, specific can suppress However, not all act this manner example, mismatch repair factors MSH2 MLH 1) hereditary nonpolyposis colorectal (HNPCC) inhibit proliferation, but prevent further mutations (10–12) Additionally, other have multiple functions, for example, p53 either induce cell death halt cell cycle (9,13) Functional relies host methods determine how if they Later, we will focus that have used assess antimitogenic potential pathway (2,3,7, 14) these same approaches amenable any or antimitogenic molecule Biology Books مجاناً PDF اونلاين Biologically Biology is natural science concerned with study life, its various forms function, organisms interact each surrounding environment word Greek made up two words: bio (βίος) meaning life And loggia ( λογία) means Biology: similarity vegetation animal cover edges African American states, existence fossil Branches biology Biology ancient thousands years old modern began nineteenth century branches Among them are: Anatomy Botany Biochemia Biogeography Biofisia Cytology science Ecology environmental science Development Embryology embryology Genetics genetics Histology histology Anthropology anthropology Microbiology bacteriology Molecular Biology Physiology functions organs Taxonemia taxonomy Virology virology Zoology zoology
كتاب
Cancer Cell Signaling Methods and Protocols
ــ David M. Terrian
صدر 2010م كتاب
Cancer Cell Signaling Methods and Protocols
ــ David M. Terrian
صدر 2010م
نبذه عن الكتاب:
development, has revolutionized the molecular analysis of cancer (1–3). By definition, tumor suppressor genes are genetically linked to a cancer. For example,
the retinoblastoma (RB) tumor suppressor was first identified as a gene that
was specifically lost in familial RB (4–6). The majority of tumor suppressors
4 Knudsen and Angus
has been identified based on linkage analysis and subsequent epidemiological
studies, however, initial understanding of their mode of action was relatively
limited. As the number of tumor suppressors has increased, understanding the
mechanism through which tumor suppressors function has become an important
aspect of cancer biology.
In general, tumors exhibit uncontrolled proliferation. This phenotype can
arise from loss of tumor suppressors that regulate progression through the cell
cycle (e.g., RB or p16ink4a) or upstream mitogenic signaling (e.g., NF1 or PTEN)
cascades (1,3,7–9). Thus, specific tumor suppressors can function to suppress proliferation. However, not all tumor suppressors act in this manner. For example,
mismatch repair factors (e.g., MSH2 or MLH-1) lost in hereditary nonpolyposis
colorectal cancer (HNPCC) function not to inhibit proliferation, but to prevent
further mutations (10–12). Additionally, other tumor suppressors have multiple functions, for example, p53 can function to either induce cell death or halt
cell-cycle progression (9,13).
Functional analysis of tumor suppressors relies on a host of methods to determine how or if they inhibit proliferation. Later, we will focus on methods that
have been used to assess the antimitogenic potential of the RB-pathway (2,3,7,
14). However, these same approaches are amenable to any tumor suppressor or
antimitogenic molecule.
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