📘 ❞ Molecular Biology of the Neuron ❝ كتاب ــ Yao-Shan Fan اصدار 2002
Biology Books - 📖 ❞ كتاب Molecular Biology of the Neuron ❝ ــ Yao-Shan Fan 📖
█ _ Yao Shan Fan 2002 حصريا كتاب Molecular Biology of the Neuron 2024 Neuron: نبذه عن الكتاب: Molecular Cytogenetics in Medicine An Overview Yao Fan 1 Introduction The word “chromosome” was introduced over a century ago from Greek language meaning “colored body ” While cytogenetics refers to study chromosomes, term molecular is used describe analysis genomic alterations using mainly situ hybridization based technology Fluorescent (FISH) initially developed late 1980s from radioactive procedures for mapping human genes (1–4) Soon, this utilized characterization chromosomal rearrangements and marker chromosomes (5,6), detection microdeletions (7), and prenatal diagnosis common aneuploidies (8,9) clinical laboratories At the same time, numerous DNA probes have been commercialized, further promoting the wide spread applications Many new FISH techniques developed, including primed labeling (PRINS [10]), fiber FISH (11,12), comparative genomic (CGH) (13), chromosome microdissection (14,15), spectral karyotyping (SKY [16]), Multiple color (M FISH [17,18]), banding (19), with multiple subtelomeric (20), arraybased CGH (21,22) With current techniques, deletion or rearrangement a single gene can be detected, cryptic translocations visualized, the copy number oncogenes amplified tumor cells assessed, very complex rearrangements fully characterized Using interphase FISH, alterations can studied virtually all types tissues at any stage cell division, without need culture preparation The development of FISH past two decades has brought into molecular era, made bodies” more colorful brighter Books مجاناً PDF اونلاين Biologically Biology natural science that concerned life, its various forms function, how these organisms interact each other surrounding environment biology up words: bio (βίος) life And loggia ( λογία) means Biology: similarity vegetation animal cover on edges African American states, existence same fossil Branches biology Biology an ancient thousands years old modern began nineteenth This branches Among them are: Anatomy Botany Biochemia Biogeography Biofisia Cytology science Ecology environmental science Development Embryology embryology Genetics genetics Histology histology Anthropology anthropology Microbiology bacteriology Molecular Biology Physiology functions organs Taxonemia taxonomy Virology virology Zoology zoology
كتاب
Molecular Biology of the Neuron
ــ Yao-Shan Fan
صدر 2002م
كتاب
Molecular Biology of the Neuron
ــ Yao-Shan Fan
صدر 2002منبذه عن الكتاب:
Molecular Cytogenetics in Medicine
An Overview
Yao-Shan Fan
1. Introduction
The word “chromosome” was introduced over a century ago from the Greek language meaning “colored body.” While cytogenetics refers to the study of chromosomes, the term molecular cytogenetics is used to describe the analysis of genomic
alterations using mainly in situ hybridization based technology.
Fluorescent in situ hybridization (FISH) was initially developed in the late 1980s
from radioactive hybridization procedures used for mapping human genes (1–4). Soon,
this technology was utilized for the characterization of chromosomal rearrangements
and marker chromosomes (5,6), the detection of microdeletions (7), and the prenatal
diagnosis of common aneuploidies (8,9) in clinical cytogenetics laboratories. At the
same time, numerous DNA probes have been commercialized, further promoting the
wide-spread clinical applications of molecular cytogenetics. Many new FISH techniques have been developed, including primed in situ labeling (PRINS [10]), fiber
FISH (11,12), comparative genomic hybridization (CGH) (13), chromosome microdissection (14,15), spectral karyotyping (SKY [16]), Multiple color FISH (M-FISH
[17,18]), color banding (19), FISH with multiple subtelomeric probes (20), and arraybased CGH (21,22). With the current FISH techniques, deletion or rearrangement of a
single gene can be detected, cryptic chromosome translocations can be visualized, the
copy number of oncogenes amplified in tumor cells can be assessed, and very complex
rearrangements can be fully characterized. Using interphase FISH, genomic alterations
can be studied in virtually all types of human tissues at any stage of cell division,
without the need of cell culture and chromosome preparation. The development of
FISH technology in the past two decades has brought cytogenetics into the molecular
era, and made the “colored bodies” more colorful and brighter.
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