📘 ❞ Combinatorial Library Methods and Protocols-Humana Press ❝ كتاب ــ Lisa Bellavance English اصدار 2002
Biology Books - 📖 كتاب ❞ Combinatorial Library Methods and Protocols-Humana Press ❝ ــ Lisa Bellavance English 📖
█ _ Lisa Bellavance English 2002 حصريا كتاب ❞ Combinatorial Library Methods and Protocols Humana Press ❝ 2024 Press: نبذه عن الكتاب: Using a Noncovalent Protection Strategy to Enhance Solid Phase Synthesis Fahad Al Obeidi, John F Okonya, Richard E Austin, and Dan R S Bond 1 Introduction Since the introduction of solid phase peptide synthesis by Merrifield (1) nearly forty years ago, techniques have been applied to the construction variety biopolymers extended into field small molecule The last decade has seen emergence phase synthesis as leading technique in development production of combinatorial libraries diverse compounds varying sizes properties Combinatorial can be classified biopolymer based (e g , peptides, peptidomimetics, polyureas, others [2,3]) or small molecule , heterocycles [4], natural product derivatives [5], inorganic complexes [6,7]) Libraries synthesized mainly use polystyrenedivinylbenzene (PS) derived supports Owing physical chemical limitations PS resins, other resins developed (8,9) Most of these are prepared from functionalizing resin beads with oligomers improve solvent compatibility stability Solid offers several attractive features over solution phase synthesis: (1) Molecules while covalently linked support, facilitating removal excess reagents solvents (2) solidsupported reaction driven completion through excess, soluble (3) Mechanical losses minimized compound–polymer beads remain single vessels throughout (4) Physical manipulations easy, rapid, amenable automation (5) physical separation centers on furnishes “pseudo dilution Biology Books مجاناً PDF اونلاين Biologically Biology is science that concerned with study life, its various forms function, how organisms interact each surrounding environment word biology Greek made up two words: bio (βίος) meaning life And loggia ( λογία) means Biology: similarity vegetation animal cover edges African American states, existence same fossil Branches biology Biology an ancient thousands old modern began nineteenth century This multiple branches Among them are: Anatomy Botany Biochemia Biogeography Biofisia Cytology cell science Ecology environmental science Development Embryology embryology Genetics genetics Histology histology Anthropology anthropology Microbiology bacteriology Molecular Biology Physiology functions organs Taxonemia taxonomy Virology virology Zoology zoology
كتاب
Combinatorial Library Methods and Protocols-Humana Press
ــ Lisa Bellavance English
صدر 2002م
كتاب
Combinatorial Library Methods and Protocols-Humana Press
ــ Lisa Bellavance English
صدر 2002منبذه عن الكتاب:
Using a Noncovalent Protection Strategy
to Enhance Solid-Phase Synthesis
Fahad Al-Obeidi, John F. Okonya, Richard E. Austin,
and Dan R. S. Bond
1. Introduction
Since the introduction of solid-phase peptide synthesis by Merrifield (1)
nearly forty years ago, solid-phase techniques have been applied to the
construction of a variety of biopolymers and extended into the field of small
molecule synthesis. The last decade has seen the emergence of solid-phase
synthesis as the leading technique in the development and production of
combinatorial libraries of diverse compounds of varying sizes and properties.
Combinatorial libraries can be classified as biopolymer based (e.g., peptides,
peptidomimetics, polyureas, and others [2,3]) or small molecule based (e.g.,
heterocycles [4], natural product derivatives [5], and inorganic complexes
[6,7]). Libraries synthesized by solid-phase techniques mainly use polystyrenedivinylbenzene (PS) derived solid supports. Owing to physical and chemical
limitations of PS-derived resins, other resins have been developed (8,9). Most
of these resins are prepared from PS by functionalizing the resin beads with
oligomers to improve solvent compatibility and physical stability (8,9).
Solid-phase synthesis offers several attractive features over solution-phase
synthesis: (1) Molecules are synthesized while covalently linked to the solid support, facilitating the removal of excess reagents and solvents. (2) The solidsupported reaction can be driven to completion through the use of excess,
soluble reagents. (3) Mechanical losses are minimized as the compound–polymer
beads remain in single-reaction vessels throughout the synthesis. (4) Physical
manipulations are easy, rapid, and amenable to automation. (5) The physical
separation of the reaction centers on resin furnishes a “pseudo-dilution
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