📘 ❞ Cell Protocols_ Development and Activation-Humana Press ❝ كتاب ــ Kelly P. Kearse اصدار 2000
Biology Books - 📖 كتاب ❞ Cell Protocols_ Development and Activation-Humana Press ❝ ــ Kelly P. Kearse 📖
█ _ Kelly P Kearse 2000 حصريا كتاب ❞ Cell Protocols_ Development and Activation Humana Press ❝ 2024 Press: نبذه عن الكتاب: T cell differentiation is a tightly controlled developmental program observed as the stepwise progression of immature thymocytes through several unique stages characterized by expression distinct combinations surface markers The advancement from one stage to next requires the successful completion or more specific processes, accompanied acquisition receptors, which signal transit through certain critical checkpoints mature techniques of transgenesis germ line targeting are particularly useful in study such complex programs, that players can be manipulated in context an otherwise unaltered environment Such studies have been instrumental our understanding not only how number thymocyte surface receptors involved program, but also identifying some intracellular signaling mediators regulation of transcription factors ultimately responsible for orchestrating the differentiated phenotype It clear investigation molecular details T development has benefited greatly transgenic knockout methodology we shall discuss few examples key experiments present chapter We shall attempt provide comprehensive overview all genes that have been targeted expressed, as excellent up date reviews available Our aim illustrate role these components was elucidated interpretation within the framework what now fairly well established pathway thymocyte differentiation Biology Books مجاناً PDF اونلاين Biologically Biology natural science concerned with life, its various forms function, organisms interact each other surrounding word biology Greek made two words: bio (βίος) meaning life And loggia ( λογία) means Biology: similarity vegetation animal cover on edges African American states, existence same fossil Branches biology Biology ancient thousands years old modern began nineteenth century This multiple branches Among them are: Anatomy Botany Biochemia Biogeography Biofisia Cytology science Ecology environmental science Development Embryology embryology Genetics genetics Histology histology Anthropology anthropology Microbiology bacteriology Molecular Biology Physiology functions organs Taxonemia taxonomy Virology virology Zoology zoology
كتاب
Cell Protocols_ Development and Activation-Humana Press
ــ Kelly P. Kearse
صدر 2000م كتاب
Cell Protocols_ Development and Activation-Humana Press
ــ Kelly P. Kearse
صدر 2000م
نبذه عن الكتاب:
T-cell differentiation is a tightly controlled developmental program observed
as the stepwise progression of immature thymocytes through several unique
stages characterized by the expression of distinct combinations of cell surface
markers. The advancement of thymocytes from one stage to the next requires
the successful completion of one or more specific developmental processes,
accompanied by the acquisition of receptors, which signal a cell to transit
through certain critical checkpoints to a more mature stage. The techniques of
transgenesis and germ-line targeting are particularly useful in the study of such
complex developmental programs, in that specific players can be manipulated
in the context of an otherwise unaltered environment. Such studies have been
instrumental in our understanding not only of how a number of thymocyte surface receptors are involved in the developmental program, but also in identifying some of the intracellular signaling mediators that are involved in regulation
of transcription factors which are ultimately responsible for orchestrating the
differentiated phenotype.
It is clear that the investigation of the molecular details of T-cell development has benefited greatly from transgenic and knockout methodology and we
shall discuss a few examples of some key experiments in the present chapter.
We shall not attempt to provide a comprehensive overview of all the genes that
have been targeted or expressed, as some excellent up-to-date reviews are available. Our aim is to illustrate how the role of a few of these molecular components was elucidated and discuss the interpretation of these experiments within
the framework of what is now a fairly well established pathway of thymocyte
differentiation
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