📘 ❞ Thyroid Hormone Receptors. Methods and Protocols ❝ كتاب ــ Aria Baniahmad اصدار 2002
Biology Books - 📖 ❞ كتاب Thyroid Hormone Receptors. Methods and Protocols ❝ ــ Aria Baniahmad 📖
█ _ Aria Baniahmad 2002 حصريا كتاب Thyroid Hormone Receptors Methods and Protocols 2024 Protocols: نبذه عن الكتاب: Thyroid hormone receptors (TRs) play a major role in animal physiology TRs are important very interesting regulators of diverse aspects, including brain development, hearing, bone growth, morphogenesis, metabolism, intestine, heart rate vertebrates (Fig 1) Aberrant functions TRs induce tremendous defects these pathways For example, the human disease of Resistance to (RTH) (see Chapter 8 by Yoh Privalsky) is genetically autosomal dominant inherited syndrome that is caused mutations gene encoding TRβ The ligand TRs, thyroid hormone, modulate activity functionality Two separate genes encode two highly homologous TRα The localized on chromosome 17, while 3 harbors the locus Each encodes for several isoforms due alternative splicing promoter usage 2) (1–3) expression patterns of TRα different, although overlapping developing adult tissue (4–6) Also, splice variants various products from both TRα and loci, which derived usage, exhibit a distinct profile Since naturally occurring “truncated” receptors affect full length different levels profiles result differing specificity TR action modulation thyroid response Biology Human biology Who founder biology? The importance biology Areas work field biology Theories biology Research biology first grade secondary school Human Biology Books مجاناً PDF اونلاين Biologically Biology natural science concerned with study life, its forms function, how organisms interact each other surrounding environment word Greek made up words: bio (βίος) meaning life And loggia ( λογία) means or Biology: similarity vegetation cover edges African American states, existence same fossil Branches biology Biology an ancient thousands years old modern began nineteenth century This has multiple branches Among them are: Anatomy Botany Biochemia Biogeography Biofisia Cytology cell science Ecology environmental science Development Embryology embryology Genetics genetics Histology histology Anthropology anthropology Microbiology bacteriology Molecular Biology Physiology organs Taxonemia taxonomy Virology virology Zoology zoology
كتاب
Thyroid Hormone Receptors. Methods and Protocols
ــ Aria Baniahmad
صدر 2002م
كتاب
Thyroid Hormone Receptors. Methods and Protocols
ــ Aria Baniahmad
صدر 2002منبذه عن الكتاب:
Thyroid hormone receptors (TRs) play a major role in animal physiology.
TRs are important and very interesting regulators of diverse aspects, including
brain development, hearing, bone growth, morphogenesis, metabolism, intestine, and heart rate in vertebrates (Fig. 1). Aberrant functions of TRs induce
tremendous defects in these pathways. For example, the human disease of
Resistance to Thyroid Hormone (RTH) (see Chapter 8 by Yoh and Privalsky)
is a genetically autosomal dominant inherited syndrome that is caused by mutations in the gene encoding the TRβ. The role of the ligand of TRs, the thyroid
hormone, is to modulate the activity and functionality of TRs.
Two separate genes encode two highly homologous TRs, TRα and TRβ.
The TRα gene is localized on chromosome 17, while chromosome 3 harbors
the TRβ locus. Each gene encodes for several isoforms due to alternative splicing and alternative promoter usage (Fig. 2) (1–3). The expression patterns of
TRα and TRβ are different, although overlapping in developing and adult tissue (4–6). Also, splice variants and the various gene products from both TRα
and TRβ gene loci, which are derived from alternative promoter usage, exhibit
a distinct expression profile. Since these naturally occurring “truncated”
receptors affect the functionality of the full-length TRs, the different expression levels and expression profiles result in differing tissue specificity of TR
action and modulation of thyroid hormone response
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