📘 ❞ Antiviral Methods and Protocols ❝ كتاب ــ كاتب غير معروف اصدار 1999

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█ _ كاتب غير معروف 1999 حصريا كتاب Antiviral Methods and Protocols 2024 Protocols: نبذه عن الكتاب: Changing for Discovering Drugs Philip S Jones 1 Introduction Viral diseases were largely untreatable 40 yr ago Now effective safe therapies are available This has led to significant improvements in the quality of life large numbers of patients New viral are, however, continuing emerge established viruses have been shown develop resistance to available therapies making this a fertile area continued drug discovery The processes used discover drugs also changed enormously over past 40 Nowhere these changes more apparent than field of antiviral therapy Therefore, development antiviral makes an excellent example documenting approaches discover active agents brief chapter describes some changes—from the broad screening animals tissue culture first mechanism–based approaches using computer assisted techniques biostructural information 2 Beginnings The origins can be traced early 1950s, when sulfonamide antibiotics tested activity against poxviruses mice infected with vaccinia (1) A decade work at Wellcome laboratories culminated methisazone, which was introduced 1960 for the prophylaxis smallpox (see Scheme 1) Notable success smallpox epidemic Madras 1963 demonstrated value compound, but vaccines soon after eradication disease made the compound redundant However, principle that chemotherapy effective for treating had Biology Books مجاناً PDF اونلاين Biologically Biology is natural science concerned study life, its various forms function, how organisms interact each other surrounding environment The word biology Greek up two words: bio (βίος) meaning And loggia ( λογία) means or Biology: similarity vegetation animal cover on edges African American states, existence same fossil Branches biology Biology an ancient thousands years old modern began nineteenth century multiple branches Among them are: Anatomy Botany Biochemia Biogeography Biofisia Cytology cell science Ecology environmental science Development Embryology embryology Genetics genetics Histology histology Anthropology anthropology Microbiology bacteriology Molecular Biology Physiology functions organs Taxonemia taxonomy Virology virology Zoology zoology

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Antiviral Methods and Protocols
كتاب

Antiviral Methods and Protocols

ــ كاتب غير معروف

صدر 1999م
Antiviral Methods and Protocols
كتاب

Antiviral Methods and Protocols

ــ كاتب غير معروف

صدر 1999م
عن كتاب Antiviral Methods and Protocols:
نبذه عن الكتاب:

Changing Methods for Discovering Antiviral Drugs
Philip S. Jones
1. Introduction
Viral diseases were largely untreatable 40 yr ago. Now effective and safe
therapies are available. This has led to significant improvements in the quality
of life for large numbers of patients. New viral diseases are, however, continuing to emerge and established viruses have been shown to develop resistance to
available therapies making this a fertile area for continued drug discovery. The
processes used to discover drugs have also changed enormously over the past
40 yr. Nowhere have these changes been more apparent than in the field of
antiviral therapy. Therefore, the development of antiviral drugs makes an
excellent example for documenting the changes in approaches used to discover
active agents. This brief chapter describes some of these changes—from the
broad screening in animals and tissue culture first used to the mechanism–based
approaches using computer assisted techniques and biostructural information.
2. Beginnings
The origins of antiviral therapies can be traced to the early 1950s, when
sulfonamide antibiotics were tested for activity against poxviruses using mice
infected with vaccinia (1). A decade of work at the Wellcome laboratories culminated in the development of methisazone, which was introduced in 1960 for
the prophylaxis of smallpox (see Scheme 1). Notable success in the smallpox
epidemic in Madras in 1963 demonstrated the value of this compound, but
vaccines introduced soon after led to eradication of the disease and made the
compound redundant. However, the principle that chemotherapy was effective
for treating antiviral diseases had been demonstrated.
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