📘 ❞ Tumor Suppressor Genes Pathways and Isolation Strategies ❝ كتاب ــ Wafik S. El-Deiry, MD, PhD
Biology Books - 📖 ❞ كتاب Tumor Suppressor Genes Pathways and Isolation Strategies ❝ ــ Wafik S. El-Deiry, MD, PhD 📖
█ _ Wafik S El Deiry, MD, PhD 0 حصريا كتاب Tumor Suppressor Genes Pathways and Isolation Strategies 2024 Strategies: نبذه عن الكتاب: Growth Control by the Retinoblastoma Gene Family Marco G Paggi, Armando Felsani, Antonio Giordano 1 Introduction 1 1 The Family The family consists of three genes, RB, p107, Rb2 p130, all fundamental in control important cellular phenomena, such as cell cycle, differentiation, apoptosis “founder” most investigated gene is RB, which considered prototype for tumor suppressor genes (1,2) other two genes, p107 proteins they code for, pRb2 respectively, clearly reflect a high degree structural functional similarity to RB gene product, pRb (3,4) RB were disclosed initially investigators working on viral oncoproteins In particular, set associated with the Adenovirus 5 E1A oncoprotein was identified, bands representing most abundant ones named p60, p105, p300, keeping their apparent molecular mass, determined SDS PAGE (5) subsequent characterization these identified p105 product (6) Later, genes encoding (7,8) p130 (9–11) cloned using different strategies In essence, structure products, pRb, and pRb2 consist (a) an N terminal portion, (b) “pocket structure” subdivided into domain A, spacer, B, (c) C k (3) The pocket domains A B are conserved among RB family members responsible interactions involving either some endogenous proteins, those E2F (3,4,12–14), or oncoproteins, i e , Adenovirus E1A, SV40 large T, Human Papillomavirus E7 (6,7,15–20) A common relevant biological feature shared this is the ability cycle (8,21–23) fact, negatively modulate transition between G1 phases, utilizing mechanisms mostly related inactivation of transcription factors, family, that promote cell’s entrance into phase (3,4,12–14) role key negative cycle regulators mainly modulated posttranslational modifications, important one being phosphorylation well known substrate kinase phosphatase activity, thus undergoing extensive Biology Books مجاناً PDF اونلاين Biologically Biology natural science concerned study life, its various forms function, how organisms interact each surrounding environment word biology Greek made up two words: bio (βίος) meaning life And loggia ( λογία) means Biology: vegetation animal cover edges African American states, existence same fossil Branches biology Biology ancient thousands years old modern began nineteenth century This has multiple branches Among them are: Anatomy Botany Biochemia Biogeography Biofisia Cytology science Ecology environmental science Development Embryology embryology Genetics genetics Histology histology Anthropology anthropology Microbiology bacteriology Molecular Biology Physiology functions organs Taxonemia taxonomy Virology virology Zoology zoology
كتاب
Tumor Suppressor Genes Pathways and Isolation Strategies
ــ Wafik S. El-Deiry, MD, PhD
كتاب
Tumor Suppressor Genes Pathways and Isolation Strategies
ــ Wafik S. El-Deiry, MD, PhD
نبذه عن الكتاب:
Growth Control by the Retinoblastoma Gene Family
Marco G. Paggi, Armando Felsani, and Antonio Giordano
1. Introduction
1.1. The Retinoblastoma Gene Family
The Retinoblastoma family consists of three genes, RB, p107, and Rb2/p130, all fundamental in the control of important cellular phenomena, such as cell cycle, differentiation, and apoptosis. The “founder” and the most investigated gene of the family is RB,
which is considered the prototype for the tumor suppressor genes (1,2). The other two
genes, p107 and Rb2/p130, and the proteins they code for, p107 and pRb2/p130, respectively, clearly reflect a high degree of structural and functional similarity to the RB
gene product, pRb (3,4). The RB family proteins were disclosed initially by investigators working on viral oncoproteins. In particular, a set of proteins associated with the
Adenovirus 5 E1A oncoprotein was identified, and the bands representing the most
abundant ones were named p60, p105, p107, p130, and p300, in keeping with their apparent molecular mass, as determined by SDS-PAGE (5). The subsequent characterization of these proteins identified p105 as the product of the RB gene (6). Later, genes
encoding p107 (7,8) and pRb2/p130 (9–11) were cloned using different strategies.
In essence, the structure of the three RB family gene products, pRb, p107, and
pRb2/p130, consist of (a) an N-terminal portion, (b) a “pocket structure” subdivided
into domain A, spacer, and domain B, and (c) a C-terminal portion, a.k.a. domain C (3).
The pocket functional domains A and B are the most conserved among the three RB
family members and are responsible for most of the interactions involving either some
endogenous proteins, such as those of the E2F family (3,4,12–14), or viral oncoproteins,
i.e., Adenovirus 5 E1A, SV40 large T, and Human Papillomavirus E7 (6,7,15–20).
A common relevant biological feature shared by the three members of this family is
the ability to control the cell cycle (8,21–23). In fact, they negatively modulate the transition between the G1 and S phases, utilizing mechanisms mostly related to inactivation
of transcription factors, such as those of the E2F family, that promote the cell’s entrance
into the S phase (3,4,12–14). The role of the RB family proteins as key negative cell cycle
regulators is mainly modulated by posttranslational modifications, the most important
one being phosphorylation. In fact, the RB gene product is a well-known substrate for either kinase or phosphatase activity, thus undergoing extensive
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